Monitoring Normal Distribution of Baseline Scores Provides Quality Control

As part of its rigorous internal QC program, MedAvante carefully monitors its own raters score distributions by visit to ensure a normal distribution. In every trial conducted by MedAvante raters, their baseline scores were statistically normally distributed.

In summary, MedAvante centralized expert raters are:

• blind to visit order history
• independent of the site
• able to achieve highest inter-rater reliability in industry
• certain to increase study power and/or allow reducing sample sizes
• able to guarantee appropriate patient selection 

By carefully controlling reliability, bias and interview quality, MedAvante dramatically enhances signal detection in CNS clinical trials.  The result for sponsors is certainty in maximizing the value proposition for their CNS products, minimizing uncertainty about their product’s efficacy, positioning, and pricing as well as delivering effective therapies for treating debilitating CNS diseases.